daw
09-24-2003, 01:38 AM
These are articles from Entrez Pubmed.
....and they are from 1978 and 1980.
Anesthesiology. 1980 Apr;52(4):321-3.
Effect of domperidone on lower esophageal sphincter tone in late pregnancy.
Brock-Utne JG, Downing JW, Dimopoulos GE, Rubin J, Moshal MG.
Increasing the resting lower esophageal sphincter (LES) tone is a useful method of preventing gastroesophageal reflux. The effects of a new antiemetic, domperidone, on LES were studied in 28 subjects. Group I included eight normal nonpregnant control subjects. The remaining 20 pregnant women were divided into two groups, Group II and III--ten parturients without and ten with symptoms of heartburn. Domperidone increased LES pressure by 19, 11 and 10 cm H2O in Groups I, II and III, respectively (P less than 0.05). Domperidone may be avaluable premedicant in some patients to decrease the chance of gastro-esophageal reflux.
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Anesth Analg. 1980 Dec;59(12):921-4.
Domperidone antagonizes the relaxant effect atropine on the lower esophageal sphincter.
Brock-Utne JG.
A zone of increased intraluminal pressure exists at the gastroesophageal junction in man and is believed to act as a physiologic sphincter. Increasing this lower esophageal sphincter (LES) tone is an accepted and useful method in preventing gastroesophageal reflux. The effects of LES tone were studied in 10 healthy volunteers receiving sequential intravenous injections of atropine, 0.6 mg, or domperidone, 10 mg, followed by domperidone, 10 mg, or atropine, 0.6 mg. The order of drug administration was randomized during the first study. Each volunteer was studied a second time, 1 week later, when the order of drug administration was reversed from the first. Administration of atropine decreased mean LES pressure by 12.6 cm H2O (p < 0.001). Subsequent injection of domperidone restored LES tone to near normal. In contrast, initial injection of domperidone approximately 1 week later in the same subjects, mean LES pressure increased by 18.5 cm H2O (p < 0.001). Intravenous injection of atropine, thereafter, failed to decrease mean LES pressure significantly, LES pressure being sustained at a mean of 14.8 cm H2O above basal control levels (p < 0.005). Results of this study suggest that domperidone given prior to atropine, before induction of general anesthesia, may counteract the potentially deleterious effect of atropine on LES tone, and thereby reduce the chances of regurgitation and pulmonary aspiration of acid gastric contents.
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Br J Anaesth. 1978 Mar;50(3):295-8.
The action of commonly used antiemetics on the lower oesophageal sphincter.
Brock-Utne JG, Rubin J, Welman S, Dimopoulos GE, Moshal MG, Downing JW.
The effects of five antiemetic drugs on the lower oesophageal sphincter (LOS) were studied in five groups, each comprising eight healthy volunteers. Cyclizine, prochlorperazine and metoclopramide have a desirable functional effect on LOS, while promethazine and droperidol were associated with evidence of increased gastro-oesophageal reflux.
Domperidone (Motillium) not availble in US.
Prochlorperazine (Compazine)
Metoclopramide (Reglan)
Promethazine (Phenergan)
Droperidol (Inapsine)
....and they are from 1978 and 1980.
Anesthesiology. 1980 Apr;52(4):321-3.
Effect of domperidone on lower esophageal sphincter tone in late pregnancy.
Brock-Utne JG, Downing JW, Dimopoulos GE, Rubin J, Moshal MG.
Increasing the resting lower esophageal sphincter (LES) tone is a useful method of preventing gastroesophageal reflux. The effects of a new antiemetic, domperidone, on LES were studied in 28 subjects. Group I included eight normal nonpregnant control subjects. The remaining 20 pregnant women were divided into two groups, Group II and III--ten parturients without and ten with symptoms of heartburn. Domperidone increased LES pressure by 19, 11 and 10 cm H2O in Groups I, II and III, respectively (P less than 0.05). Domperidone may be avaluable premedicant in some patients to decrease the chance of gastro-esophageal reflux.
--------------------------------------------------
Anesth Analg. 1980 Dec;59(12):921-4.
Domperidone antagonizes the relaxant effect atropine on the lower esophageal sphincter.
Brock-Utne JG.
A zone of increased intraluminal pressure exists at the gastroesophageal junction in man and is believed to act as a physiologic sphincter. Increasing this lower esophageal sphincter (LES) tone is an accepted and useful method in preventing gastroesophageal reflux. The effects of LES tone were studied in 10 healthy volunteers receiving sequential intravenous injections of atropine, 0.6 mg, or domperidone, 10 mg, followed by domperidone, 10 mg, or atropine, 0.6 mg. The order of drug administration was randomized during the first study. Each volunteer was studied a second time, 1 week later, when the order of drug administration was reversed from the first. Administration of atropine decreased mean LES pressure by 12.6 cm H2O (p < 0.001). Subsequent injection of domperidone restored LES tone to near normal. In contrast, initial injection of domperidone approximately 1 week later in the same subjects, mean LES pressure increased by 18.5 cm H2O (p < 0.001). Intravenous injection of atropine, thereafter, failed to decrease mean LES pressure significantly, LES pressure being sustained at a mean of 14.8 cm H2O above basal control levels (p < 0.005). Results of this study suggest that domperidone given prior to atropine, before induction of general anesthesia, may counteract the potentially deleterious effect of atropine on LES tone, and thereby reduce the chances of regurgitation and pulmonary aspiration of acid gastric contents.
--------------------------------------------------
Br J Anaesth. 1978 Mar;50(3):295-8.
The action of commonly used antiemetics on the lower oesophageal sphincter.
Brock-Utne JG, Rubin J, Welman S, Dimopoulos GE, Moshal MG, Downing JW.
The effects of five antiemetic drugs on the lower oesophageal sphincter (LOS) were studied in five groups, each comprising eight healthy volunteers. Cyclizine, prochlorperazine and metoclopramide have a desirable functional effect on LOS, while promethazine and droperidol were associated with evidence of increased gastro-oesophageal reflux.
Domperidone (Motillium) not availble in US.
Prochlorperazine (Compazine)
Metoclopramide (Reglan)
Promethazine (Phenergan)
Droperidol (Inapsine)